Synthesis of 5-Aminolevulinic Acid from 1,5-Dihydroxy-2-pyridone via Piperidine-2,5-dione.
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چکیده
منابع مشابه
Porphyrin Synthesis from 5-Aminolevulinic Acid in Patients with Glioma
The molecule 5-aminolevulinic acid (5-ALA) is a substrate for a heme synthesized in cells us‐ ing succinyl CoA and glycine. Initially, 5-ALA is converted to porphobilinogen (PBG), and the metabolism progresses by the action of PBG deaminase, and its product is incorporated into the mitochondria via uroporphyrinogen and coproporphyrinogen by an enzymatic reaction and transformed into protoporphy...
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A hemA mutant of Escherichia coli containing a multicopy plasmid which complemented the mutation excreted 5-aminolevulinic acid (ALA) into the medium. [1-14C]glutamate was substantially incorporated into ALA by this strain, whereas [2-14C]glycine was not. Periodate degradation of labeled ALA showed that C-5 of ALA was derived from C-1 of glutamate. The synthesis of ALA by two sonicate fractions...
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The crystal structure of the title compound, C(6)H(7)NO, is stabilized by inter-molecular N-H⋯O hydrogen bonds, resulting in inversion dimers. The structure is further consolidated by weak C-H⋯O hydrogen bonds.
متن کامل5-Aminolevulinic acid synthesis in epimastigotes of Trypanosoma cruzi.
BACKGROUND AND AIMS Trypanosoma cruzi is the causative agent of Chagas disease or American trypanosomiasis. The parasite manifests a nutritional requirement for heme compounds because of its biosynthesis deficiency. The aim of this study has been to investigate the presence of metabolites and enzymes of porphyrin pathway, as well as ALA formation in epimastigotes of T. cruzi, Tulahuén strain, T...
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The long-term treatment of chronic uremic patients with intermittent dialysis has led to an increase in the life span of these individuals. A number of low-molecular-weight compounds accumulate in body fluids of uremic patients and may contribute to the toxic features of uremia. Many of these are removed by hemodialysis. Most frequently hemodialysis is accompanied by improvement of the patient ...
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ژورنال
عنوان ژورنال: NIPPON KAGAKU KAISHI
سال: 1999
ISSN: 2185-0925,0369-4577
DOI: 10.1246/nikkashi.1999.355